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It is a disorder that affects the nervous system and the parts of the body controlled by the nerves, affects movement and usually causes tremors.
Parkinson’s disease is a neurodegenerative disease of the central nervous system whose main characteristic is the progressive death of neurons in a part of the brain.
The most important consequence of this neuronal loss is a marked decrease in the brain availability of dopamine, the main substance synthesized by these neurons, causing a dysfunction in the regulation of the main brain structures involved in the control of movement.
Symptoms mainly affect the patient’s motor function, starting on one side of the body. The most characteristic are:
Typical manifestations are also the facial inexpressiveness, the scarcity of automatic movements such as blinking or brachiation when walking, the inclination of the trunk forward during the march, etc.
Parkinson’s disease is a clinically diagnosed disease. The neurologist makes the diagnosis based on a detailed anamnesis with the data provided by the patient and his family and the findings of the physical examination. It is not strictly necessary to perform complementary tests.
The evolution of Parkinson’s disease is very variable so that in some patients the neurodegenerative process progresses very slowly while in others it may be faster. In general, as the duration of the disease increases, the initial movement disorders become more intense in the hemibody where they started and manifest in the other hemibody.
In addition, other symptoms may appear such as:
With no current therapies to recover from critical cell death, MSCs provide an alternative route to potentially restore a disease-free state.
Mesenchymal stem cells are considered an attractive therapeutic candidate because of their high self-renewal capacity, lack of adverse effects in allogeneic versus autologous transplants, high ethical acceptability, and no teratoma formation.
Intravenous MSC therapy can be considered an ideal source for replacing lost cells in degenerative diseases such as Parkinson’s disease, since the treatment is based on the cells’ potential for differentiation into dopaminergic neurons.
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